However, patients that are older, have received several prior treatments, or have other organ diseases are at a high risk of getting life-threatening treatment-related side effects from high doses of chemotherapy. Usually, patients are given very high doses of chemotherapy (drugs which kill cancer cells) prior to receiving a stem cell transplant. In a transplant, the body's stem cells would be killed and then replaced by stem cells from the donor. They grow into different types of blood cells that the body needs, including red blood cells, white blood cells, and platelets. Stem cells are created in the bone marrow. Why Should I Register and Submit Results?īlood disorders such as leukemia or lymphoma or hemoglobinopathies can benefit from receiving an allogeneic (meaning that the cells are from a donor) stem cell transplant.Strong construction work and a great theme, opaque to me until the last lamb had flown. Overall, a really nice piece of work from Ed to start the week.
I'd love to see less use of these in Monday grids. The trickiest places of a grid arrangement like this are usually the west and east sections because of the pile-up of parallel down constraints, and there are some compromises today: PLENA is a very tough word for a Monday, and the ETE/OREM/REATA pileup isn't ideal.Īdditionally, EL AL and ALERO aren't very well known in the general American public (EL AL is an Israeli airline and the ALERO was discontinued in 2004). It might seem like the theme answers are basically equivalent to four grid-spanners, but the fact that the four middle themers are offset by one row makes it more that much more difficult to fill the grid (in general, the more spacing between theme answers the better). And to have each of the four dogs at the end of a "leash" (tagged onto another word), that's pretty darn cool. I hadn't seen the grid-spanning theme answers as fences of a kennel, but now it's plain as day. I blame my shaky grasp of reality.īeautiful layout today, which I appreciated even more after my e-mail exchange with Ed. Not totally sure why I thought lambs could fly. The fact that my muddled brain led me to believe it was WHERE OH WHERE HAS MY LITTLE LAMB FLOWN elevated the a-ha moment when DOG appeared. But I didn't cotton to today's theme until the very end and got a great a-ha moment when I realized four common dog names were hidden in plain sight at the end of four snappy phrases. It's not often that a Monday puzzle surprises me, since Monday themes usually must be easy-breezy, appropriate for beginner level solvers. This here, folks, is a great week to be doing the NYT crossword. So when there are weeks like this one, with all seven puzzles being solid to incredibly awesome, I can't believe my luck. I'm almost always able to find something I like and admire about a puzzle, and locating that nugget(s) of goodness brings a smile to my face. Having the opportunity to write about the NYT crossword every day, incorporating feedback from both the constructors and Will Shortz himself, has been a dream come true. I've been lucky enough to have this gig for ten weeks now, and what a ride it's been.
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